Computational study on the effectiveness of flavonoids from Marsilea crenata C. Presl as potent SIRT1 activators and NFκB Inhibitors

Ovarian aging is a natural process in females, and it occurs due to an elevated ROS-induced inflammation caused by oxidative stress. SIRT-1 metabolic sensor that tightly regulates inflammatory responses. However, this regulative function antagonized NFκB. Therefore, the objective of study was explore pathways involved identify flavonoid compounds from Marsilea crenata might be useful as SIRT1 activators NFκB inhibitors. The screening began with exploring protein-protein interaction experimental using BioGrid, role evaluated STITCH. between hyperoside, luteolin, naringenin, quercetin against determined through molecular docking, while their toxicity also evaluated. present result demonstrated seven proteins were similar pathways. STITCH showed six aging, shown interact SIRT1. docking hyperoside exhibited activator for dimeric, heterodimeric, heterotrimeric chains inhibitor p52-RelB, p50-p65 complex, IκK, had best binding affinity compared other flavonoids. These flavonoids potentially have at least one characteristic. In conclusion, M. promising inhibitors